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DNases I could degrade NETs DNA backbone, and several clinical trials showed protective effects of rhDNase1 in COVID-19 patients, which could reduce inflammation (135, 142)

This elevated TIMP-to-MMP ratio creates an environment where damaged tissue gets cleaned up while new tissue gets protected

GSH turnover may be considered as a multi-organ process

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Trial designs that implement inductionmaintenance sequences, co-primary mechanistic and clinical endpoints, longer follow-up for durability, and head-to-head comparisons under harmonized outcome sets are priorities